The LSM5 antibody (clone AT25F8) from MyBioSource.com is a Mouse Monoclonal antibody to LSM5. This antibody recognizes Human antigen. The LSM5 antibody (clone AT25F8) has been validated for the following applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Anti-human LSM5 mAb, clone AT25F8, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human LSM5 protein.
LSM5, also known as YER146W, is a 91 amino acid protein belonging to the snRNP Sm family. Localized to the nucleus, LSm5 has been found to play a role in the formation and function of the U6 snRNP. Specifically, LSm5 binds to the 3' end of U6 snRNA and facilitates U4/U6 duplex formation. Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing